Production of three-dimensional silk fibroin nanofiber non-woven fabric by wet electrospinning
-
- Kishimoto Yuki
- Faculty of Textile Science and Technology, Shinshu University
-
- Kobashi Takanori
- Faculty of Textile Science and Technology, Shinshu University
-
- Morikawa Hideaki
- Faculty of Textile Science and Technology, Shinshu University Institute for Fiber Engineering, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University
-
- Tamada Yasushi
- Faculty of Textile Science and Technology, Shinshu University Institute for Fiber Engineering, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University
Search this article
Abstract
<p>Three-dimensional (3D) silk fibroin (SF) nanofiber non-woven fabric was fabricated by wet electrospinning (WES) using SF aqueous spinning solution and a liquid bath as a collector. Citric acid buffered solution at pH 3.8 supplemented with t-butyl alcohol (t-BuOH) was used as the liquid bath. The t-BuOH concentration influenced the apparent pore size and porosity of the WES non-woven fabric. The maximum pore size was formed at 30% of t-BuOH. The as-spun WES non-woven fabric structure had a crystallized form. Cell adhesion on the WES non-woven fabric was lower than that produced on the non-woven fabric by traditional dry electrospinning (DES), but no difference was observed in cell proliferation rates between WES and DES non-woven fabrics. Cells adhered and proliferated on both the surface and the inner spaces of WES non-woven fabric, although cells adhered only on the surface of DES non-woven fabric consisting of high fiber density. The WES non-woven fabric is anticipated for use as a cell scaffold mimicking an extracellular matrix in tissue.</p>
Journal
-
- The Journal of Silk Science and Technology of Japan
-
The Journal of Silk Science and Technology of Japan 25 (0), 49-57, 2017
The Japanese Society of Silk Science and Technology
- Tweet
Details 詳細情報について
-
- CRID
- 1390282680250235392
-
- NII Article ID
- 130005450604
-
- NII Book ID
- AA11828182
-
- ISSN
- 18811698
- 18808204
-
- NDL BIB ID
- 028048984
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed