Relation between change in exercise capacity and change in blood amino acids in patients with chronic heart failure

• Morotomi Nobuo

  Department of Home Care, Yumino Heart Clinic: 3-14-29 Takada, Toshima-ku, Tokyo 171-0033, Japan Department of Rehabilitation Medicine, Showa University, Japan

• Saitoh Masakazu

  Department of Physiotherapy, Sakakibara Heart Institute, Japan

• Ishii Noriko

  Department of Nursing, Sakakibara Heart Institute, Japan

• Ohno Kayoko

  Department of Nutrition, Sakakibara Heart Institute, Japan

• Nagayama Masatoshi

  Department of Cardiology, Sakakibara Heart Institute, Japan

• Kawate Nobuyuki

  Department of Rehabilitation Medicine, Showa University, Japan

• Mizuma Masazumi

  Department of Rehabilitation Medicine, Showa University, Japan

抄録

[Purpose] Although cardiac rehabilitation (CR) is recommended for patients with chronic heart failure (CHF), adequate exercise effect cannot be obtained in elderly patients. Administration of amino acids (AA) to CHF patients has been reported to improve exercise capacity, but the changes in AA composition in plasma before and after CR had not been reported. This study aimed to measure plasma levels of AA in CHF patients and compare with values of normal range. In addition the relationship between the change of exercise capacity and AA were examined. [Subjects and Methods] Twelve CHF patients (60% males, aged 68 ± 12 years) were studied. The correction between the rates of changes in exercise capacity parameters and in plasma AA levels was investigated. [Results] Anaerobic threshold (AT) and peak oxygen uptake (VO₂) improved significantly after CR. The AA profile showed no specific pattern, and citrulline (Cit) was the amino acid showing a significant positive correlation with exercise capacity (∆Cit vs. ∆AT: r=0.602, ∆Cit vs. ∆AT-work rate (WR): r=0.681, ∆Cit vs. ∆VO₂/WR: r=0.635). A tendency of positive correlation was observed between ∆Cit and ∆peak VO₂ (r=0.456). [Conclusion] The AA profile showed no specific pattern, but a relationship between change in exercise capacity and Cit were found.

収録刊行物

• Ｊ　Ｐｈｙｓ　Ｔｈｅｒ　Ｓｃｉ

  Ｊ　Ｐｈｙｓ　Ｔｈｅｒ　Ｓｃｉ 29 (3), 425-431, 2017

  理学療法科学学会

キーワード

• Chronic heart failure
• Exercise capacity
• Amino acid

詳細情報

• CRID: 1390282679308504192
• NII論文ID: 130005464953
• DOI: 10.1589/jpts.29.425
• ISSN: 21875626
• ISSN: 09155287
• Web Site: https://www.jstage.jst.go.jp/article/jpts/29/3/29_jpts-2016-868/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018092623
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
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