Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?

DOI Web Site 参考文献83件
  • Isaji Toshihiko
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University Department of Vascular Surgery, The University of Tokyo
  • Hashimoto Takuya
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University Department of Vascular Surgery, The University of Tokyo Department of Surgery, VA Connecticut Healthcare Systems
  • Yamamoto Kota
    Department of Vascular Surgery, The University of Tokyo
  • Santana Jeans M.
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University
  • Yatsula Bogdan
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University
  • Hu Haidi
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University
  • Bai Hualong
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University
  • Jianming Guo
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University
  • Kudze Tambudzai
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University
  • Nishibe Toshiya
    Department of Cardiovascular Surgery, Tokyo Medical University
  • Dardik Alan
    The Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University Department of Surgery, VA Connecticut Healthcare Systems

この論文をさがす

抄録

<p>Autogenous vein grafts remain the gold standard conduit for arterial bypass, particularly for the treatment of critical limb ischemia. Vein graft adaptation to the arterial environment, i.e., adequate dilation and wall thickening, contributes to the superior performance of vein grafts. However, abnormal venous wall remodeling with excessive neointimal hyperplasia commonly causes vein graft failure. Since the PREVENT trials failed to improve vein graft outcomes, new strategies focus on the adaptive response of the venous endothelial cells to the post-surgical arterial environment. Eph-B4, the determinant of venous endothelium during embryonic development, remains expressed and functional in adult venous tissue. After surgery, vein grafts lose their venous identity, with loss of Eph-B4 expression; however, arterial identity is not gained, consistent with loss of all vessel identity. In mouse vein grafts, stimulation of venous Eph-B4 signaling promotes retention of venous identity in endothelial cells and is associated with vein graft walls that are not thickened. Eph-B4 regulates downstream signaling pathways of relevance to vascular biology, including caveolin-1, Akt, and endothelial nitric oxide synthase (eNOS). Regulation of the Eph-B4 signaling pathway may be a novel therapeutic target to prevent vein graft failure.</p>

収録刊行物

参考文献 (83)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ