Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms

DOI 機関リポジトリ Web Site PubMed 被引用文献1件 参考文献52件
  • Tsuneyama Koichi
    Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Baba Hayato
    Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Morimoto Yuki
    Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Tsunematsu Takaaki
    Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Ogawa Hirohisa
    Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School

この論文をさがす

抄録

<p>Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an organ-specific autoimmune disease that predominantly affects middle-aged women and is characterized by the chronic progressive destruction of small intrahepatic bile ducts with portal inflammation and, ultimately, fibrosis. The serological hallmark of PBC is the presence of anti-mitochondrial autoantibodies (AMA). Several mechanisms have been proposed for immune-mediated bile duct damage in PBC, including the roles of T cells, B cells, other cell phenotypes, and AMA. A sign of fragility of biliary epithelial cells caused by apoptosis, senescence, and autophagy has also been noted. Several complex steps and mechanisms appear to be involved in the induction and progression of cholangitis and biliary degeneration in patients with PBC. J. Med. Invest. 64: 7-13, February, 2017</p>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (52)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ