A novel lipoprotein (a) lowering drug, D-47, decreases neointima thickening after vascular injury

• Nakaya Yutaka

  Department of Nutrition and Metabolism, Institute of Biomedical sciences, Tokushima University Graduate School

• Fukuda Daiju

  Department of Cardiology, Institute of Biomedical sciences, Tokushima University Graduate School

• Oyamada Takashi

  Department of Nutrition and Metabolism, Institute of Biomedical sciences, Tokushima University Graduate School

• Ogawa Kazuo

  Pharmaceutical Science, Tokushima Bunri University

• Harada Nagakatsu

  Department of Nutrition and Metabolism, Institute of Biomedical sciences, Tokushima University Graduate School

• Nakagami Hironori

  Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University

• Morishita Ryuichi

  Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University

• Sata Masataka

  Department of Cardiology, Institute of Biomedical sciences, Tokushima University Graduate School

• Sakaue Hiroshi

  Department of Nutrition and Metabolism, Institute of Biomedical sciences, Tokushima University Graduate School

Abstract

Although Lp(a) have been thought to be a cardiovascular risk factor, it is unclear whether lowering Lp(a) levels reduces the risk of cardiovascular diseases. No pharmacological agents which selectively reduce serum Lp(a) levels, and Lp(a) is present in primate but absent in common laboratory animals such as mice and pigs. In the present study we used transgenic mice of human Lp(a) and tested effect a novel Lp(a) lowering drug D-47 on neointima formation after vascular injury. D-47 successfully decreased plasma levels of Lp(a) and possibly inhibited neointima formation in Lp(a) transgenic mice. The results indicate that we can modulate plasma Lp(a) levels by pharmacologic agents and inhibit atherogenic properties of Lp(a) by reducing plasma levels of Lp(a). J. Med. Invest. 64: 64-67, February, 2017

Journal

• The Journal of Medical Investigation

  The Journal of Medical Investigation 64 (1.2), 64-67, 2017

  The University of Tokushima Faculty of Medicine

Keywords

• lipoprotein a
• atherosclerosis
• cardiovascular events
• low density lipoprotein

Details

• CRID: 1390001204245513344
• NII Article ID: 130005501982
• NII Book ID: AA11166929
• DOI: 10.2152/jmi.64.64
• ISSN: 13496867
• ISSN: 13431420
• PubMed: 28373630
• Web Site: https://repo.lib.tokushima-u.ac.jp/111083
• Web Site: https://www.jstage.jst.go.jp/article/jmi/64/1.2/64_64/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018000309
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed