Novel Artificial Coenzyme Based on the Viologen Derivative for CO₂ Reduction Biocatalyst Formate Dehydrogenase

• Ikeyama Shusaku

  Graduate School of Science, Osaka City University

• Amao Yutaka

  Graduate School of Science, Osaka City University The Advanced Research Institute for Natural Science and Technology, Osaka City University Research Center for Artificial Photosynthesis (ReCAP), Osaka City University

抄録

Formate dehydrogenase (FDH) is an attractive biocatalyst for CO₂ reduction. The reduced form of methylviologen acts as an artificial coenzyme for FDH. For further improvement in the CO₂ reduction catalytic activity of FDH, a viologen derivative with two amino groups, 1,1′-diaminoethyl-4,4′-bipyridinium salt (DA²⁺), was synthesized as the effective artificial coenzyme for FDH. By enzyme kinetic analysis, the catalytic efficiency, i.e., k_cat/K_m value of the reduced form of DA²⁺ was estimated to be more than 560 times larger than that of NADH, the natural coenzyme for FDH.

収録刊行物

• Chemistry Letters

  Chemistry Letters 45 (11), 1259-1261, 2016

  公益社団法人 日本化学会

キーワード

• CO₂ reduction
• Viologen derivative
• Artificial coenzyme

詳細情報

• CRID: 1390282679564107392
• NII論文ID: 130005509446
• DOI: 10.1246/cl.160687
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://www.journal.csj.jp/doi/pdf/10.1246/cl.160687
• 本文言語コード: en
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