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- Ito Yukako
- Department of Pharmacokinetics, Kyoto Pharmaceutical University
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- Matsumoto Kengo
- Department of Pharmacokinetics, Kyoto Pharmaceutical University
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- Osakama Noriyuki
- Department of Pharmacokinetics, Kyoto Pharmaceutical University
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- Yoshioka Ryosuke
- Department of Pharmacokinetics, Kyoto Pharmaceutical University
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- Kobuchi Shinji
- Department of Pharmacokinetics, Kyoto Pharmaceutical University
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- Sakaeda Toshiyuki
- Department of Pharmacokinetics, Kyoto Pharmaceutical University
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- Takada Kanji
- BioSerenTach Inc.
この論文をさがす
抄録
<p>The possibility of using dissolving microneedles (DMs) as a skin allergy test device was studied in rats. Poly-L-arginine was used as a model allergen. Dextran was used to prepare three kinds of DM array chips containing different doses of poly-L-arginine: 17.1±0.5 µg (low-dose DM), 42.2±0.8 µg (medium-dose DM), and 87.4±1.1 µg (high-dose DM); each 1.0 cm2 chip contained 300 DMs. The mean lengths of the low-, medium-, and high-dose DM were 489±3, 485±3, and 492±1 µm and mean diameters of the base were 301±2, 299±1, and 299±2 µm, respectively. Furthermore, for the low-, medium-, and high-dose DM, the administered doses of poly-L-arginine were estimated to be 9.3±1.9, 31.1±1.3, and 61.9±4.7 µg and the scratching behavior per 30 min was 9.8±3.4, 60.4±8.3, and 95.7±10.6 times, respectively. These results demonstrate the dose dependence of the immunoreactivity of the poly-L-arginine DMs, suggesting that DMs can be used an alternative skin allergy device.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 40 (4), 531-534, 2017
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679610560768
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- NII論文ID
- 130005530138
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 028082282
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- PubMed
- 28381808
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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- 使用不可