iPS細胞による再生と臓器移植

DOI
  • 長船 健二
    京都大学iPS細胞研究所増殖分化機構研究部門

書誌事項

タイトル別名
  • iPSC technology-based organ regeneration and transplantation

この論文をさがす

抄録

<p>The directed differentiation of human-induced pluripotent stem cells (hiPSCs) into clinically useful cell types has been vigorously examined. Transplantation methods and therapeutic potentials of hiPSC-derived cells have also been evaluated using animal disease models. Episomal vectors were successfully used to generate iPSCs without the use of viral vectors, which may cause cancer by damaging the genome. An iPSC stock derived from voluntary HLA homozygous donors is being prepared for use in regenerative therapy. These efforts have led to the start of clinical trials for the transplantation of hiPSC-derived retinal cells in Japan. Further research on reconstruction methods for functional tissues and organs from hiPSCs would resolve the problem of donor shortage in organ transplantation as well as accelerate regenerative medicine.</p>

収録刊行物

  • 移植

    移植 52 (1), 001-006, 2017

    一般社団法人 日本移植学会

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ