コエンザイムQ10摂取が高齢女性の皮膚ガス中の加齢臭成分ノネナールに与える影響  [in Japanese] Effects of Oral Administration of CoenzymeQ10 to Nonenal in Skin Gas of Elderly Women  [in Japanese]

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Abstract

コエンザイムQ10(CoQ10)摂取による体臭への影響を評価するために,皮膚ガス中のノネナールに着目して検討を行った.まず,65~74歳の健常女性20名を対象とし,プラセボ対照交差二重遮蔽比較試験を実施した.血中CoQ10濃度を指標に被験者を2群に分け,還元型CoQ10(QH)とプラセボを各4週間摂取させた(ウォッシュアウト5週間).各連用の前後で血中CoQ10濃度と皮膚ガス中のノネナール濃度を測定した結果,QH摂取群で前者は有意に上昇し(p<0.01),後者は有意に減少した(p<0.05).次に,65~74歳の健常女性24名を4群に分け,QH,酸化型CoQ10(Q10),ビタミンE及びプラセボを4週間摂取させ,その前後で皮膚ガス中のノネナールを測定した.その結果,QH,Q10の順でノネナールが減少し(p<0.01, p<0.05),ビタミンEでは変化が認められなかった.以上の検討から,QH及びCoQ10の摂取は体内から発生するノネナールを減少させると考えられた.

To evaluate the impact of coenzyme Q10 (CoQ10) intake on body odor, two studies that focused on 2-nonenal contained in the gases emanated from the skin were conducted. The first study targeted 20 healthy women aged 65–74 years in a placebo-controlled cross-comparison study. Subjects were divided into two groups using blood CoQ10 concentration as an index, with ubiquinol (QH) or placebos administered every 4 weeks (5-week washout). On measuring concentrations of CoQ10 in blood and 2-nonenal in skin gas before and after continuous use, CoQ10 level of QH intake group increased significantly, whereas 2-nonenal level reduced significantly. In the second study, 24 healthy women aged 65–74 years were divided into four groups. QH, ubiquinone, vitamin E and placebos were administered in 4 weeks, and each concentrations of 2-nonenal in skin gas were measured. QH and ubiquinone reduced 2-nonenal in skin gas; however, changes in vitamin E were not observed. Therefore, CoQ10 intake reduced 2-nonenal emanation from the body.

Journal

  • Japanese Journal of Complementary and Alternative Medicine

    Japanese Journal of Complementary and Alternative Medicine 14(1), 17-22, 2017

    The Japanese Society for Complementary and Alternative Medicine

Codes

  • NII Article ID (NAID)
    130005549194
  • NII NACSIS-CAT ID (NCID)
    AA12095429
  • Text Lang
    JPN
  • ISSN
    1348-7922
  • NDL Article ID
    028150162
  • NDL Call No.
    Z74-E199
  • Data Source
    NDL  J-STAGE 
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