Evaluation for Peritoneal Injury at an Early Stage Using Dual Macromolecular Markers
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- Hirata Haruna
- Graduate School of Biomedical Sciences, Nagasaki University
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- Fumoto Shintaro
- Graduate School of Biomedical Sciences, Nagasaki University
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- Miyamoto Hirotaka
- Graduate School of Biomedical Sciences, Nagasaki University
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- Nakashima Mikiro
- Graduate School of Biomedical Sciences, Nagasaki University
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- Nakayama Morio
- Graduate School of Biomedical Sciences, Nagasaki University
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- Nishida Koyo
- Graduate School of Biomedical Sciences, Nagasaki University
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抄録
<p>Long-term peritoneal dialysis (PD) frequently produces morphological and functional changes of the peritoneum, making continuation of PD difficult. Therefore, it is necessary to evaluate peritoneal injury at an early stage and develop appropriate therapies. The aims of the present study were to evaluate peritoneal injury at an early stage and assess a drug for prevention of peritoneal injury using our previously developed novel evaluation method. Peritoneal injury was induced in model animals by intraperitoneal injection of methylglyoxal (MGO) for 1 to 5 consecutive days or chlorhexidine digluconate (CG) for 1 to 14 consecutive days. Tetramethylrhodamine-dextran (RD)-10 and fluorescein isothiocyanate-dextran (FD)-2000 were then injected into the peritoneal cavity and recovered after 120 min to evaluate peritoneal injury. The ratio of the concentration of RD-10 to FD-2000 (RD-10/FD-2000 ratio) significantly decreased in animals that had been treated with MGO or CG for 1 d. Moreover, the RD-10/FD-2000 ratio significantly increased in CG- and thalidomide-treated animals. The RD-10/FD-2000 ratio can be used to evaluate peritoneal injury at an early stage and assess the drug efficacy of thalidomide for prevention of peritoneal injury. This study will contribute to the development of therapeutic treatments for peritoneal injury.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 39 (10), 1581-1587, 2016
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679609634944
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- NII論文ID
- 130005598443
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- HANDLE
- 10069/37300
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- NDL書誌ID
- 027623501
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- PubMed
- 27725434
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
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- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可