Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis
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- Sugawara Yuka
- Department of Nephrology and Endocrinology, The University of Tokyo, Japan
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- Honda Kenjiro
- Department of Nephrology and Endocrinology, The University of Tokyo, Japan
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- Katagiri Daisuke
- Department of Nephrology and Endocrinology, The University of Tokyo, Japan Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Japan
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- Nakamura Motonobu
- Department of Nephrology and Endocrinology, The University of Tokyo, Japan
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- Kawakami Takahisa
- Department of Nephrology and Endocrinology, The University of Tokyo, Japan
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- Nasu Ryo
- Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
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- Hayashi Akimasa
- Department of Pathology, The University of Tokyo, Japan
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- Shintani Yukako
- Department of Pathology, The University of Tokyo, Japan
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- Tojo Akihiro
- Department of Nephrology and Endocrinology, The University of Tokyo, Japan
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- Noiri Eisei
- Department of Nephrology and Endocrinology, The University of Tokyo, Japan Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Japan
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- Kurokawa Mineo
- Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Japan
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- Fukayama Masashi
- Department of Pathology, The University of Tokyo, Japan
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- Nangaku Masaomi
- Department of Nephrology and Endocrinology, The University of Tokyo, Japan Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Japan
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Abstract
<p>The development of nephrotic syndrome (NS) after umbilical cord transplantation (UBT) has been reported in only four cases to date. We herein report the case of a 50-year-old woman who developed NS 94 days after UBT. She fell into oliguria and required dialysis. A kidney biopsy revealed focal and segmental glomerulosclerosis. Although glucocorticoid monotherapy did not improve her condition, the addition of low-density lipoprotein (LDL) apheresis resulted in remission of NS, a drastic improvement in her renal function, and withdrawal from dialysis. To the best of our knowledge, this is the first report of UBT-associated NS treated with LDL apheresis. </p>
Journal
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- Internal Medicine
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Internal Medicine 55 (19), 2831-2836, 2016
The Japanese Society of Internal Medicine