ミトコンドリアを標的とする多機能性エンベロープ型ナノ構造体の創製とナノ医療への展開  [in Japanese] MITO-Porter, Multifunctional Envelope-Type Nano Device for Mitochondrial Delivery toward Innovative Nano Medicine  [in Japanese]

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Abstract

<p>A single cell contains a variety of organelles, including a nucleus, mitochondria, the golgi apparatus and others. If it were possible to prepare a nano craft that could specifically target a specific organelle, it would open a new field of research directed toward therapeutic treatments for a variety of diseases. We recently developed a new concept that we refer to as "Programmed Packaging", by which we succeeded in creating a multifunctional envelope-type nano device (MEND) as a non-viral vector. Our attempts to target mitochondria are discussed here, mainly focusing on a MITO-Porter, a MEND for delivering cargoes to mitochondria. A variety of human diseases, including various neurodegenerative disorders, ischemic heart disease, diabetes and cancer have been reported to be associated with mitochondrial dysfunction. Because of this, mitochondrial therapy would be expected to be useful and productive in the treatment of such diseases. Our findings regarding mitochondrial drug delivery systems that are directed toward mitochondrial nano medicine development are summrized herein.</p>

Journal

  • Journal of the Society of Powder Technology, Japan

    Journal of the Society of Powder Technology, Japan 54(3), 158-166, 2017

    The Society of Powder Technology, Japan

Codes

  • NII Article ID (NAID)
    130005606219
  • NII NACSIS-CAT ID (NCID)
    AN00222757
  • Text Lang
    JPN
  • ISSN
    0386-6157
  • NDL Article ID
    028049464
  • NDL Call No.
    Z17-38
  • Data Source
    NDL  J-STAGE 
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