Sterile Inflammation and Degradation Systems in Heart Failure

DOI Web Site Web Site PubMed 被引用文献2件 参考文献87件 オープンアクセス
  • Nishida Kazuhiko
    Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence
  • Otsu Kinya
    Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence

この論文をさがす

抄録

<p>In most patients with chronic heart failure (HF), levels of circulating cytokines are elevated and the elevated cytokine levels correlate with the severity of HF and prognosis. Various stresses induce subcellular component abnormalities, such as mitochondrial damage. Damaged mitochondria induce accumulation of reactive oxygen species and apoptogenic proteins, and subcellular inflammation. The vicious cycle of subcellular component abnormalities, inflammatory cell infiltration and neurohumoral activation induces cardiomyocyte injury and death, and cardiac fibrosis, resulting in cardiac dysfunction and HF. Quality control mechanisms at both the protein and organelle levels, such as elimination of apoptogenic proteins and damaged mitochondria, maintain cellular homeostasis. An imbalance between protein synthesis and degradation is likely to result in cellular dysfunction and disease. Three major protein degradation systems have been identified, namely the cysteine protease system, autophagy, and the ubiquitin proteasome system. Autophagy was initially believed to be a non-selective process. However, recent studies have described the process of selective mitochondrial autophagy, known as mitophagy. Elimination of damaged mitochondria by autophagy is important for maintenance of cellular homeostasis. DNA and RNA degradation systems also play a critical role in regulating inflammation and maintaining cellular homeostasis mediated by damaged DNA clearance and post-transcriptional regulation, respectively. This review discusses some recent advances in understanding the role of sterile inflammation and degradation systems in HF.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 81 (5), 622-628, 2017

    一般社団法人 日本循環器学会

被引用文献 (2)*注記

もっと見る

参考文献 (87)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ