MICROCRACKS DESIGN AND BONE INDUCTION OF SKULL BONE MODIFIED BY ULTRASONIC TREATMENT USING ACIDIC ELECTROLYZED WATER

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Author(s)

    • SHAKYA MAMATA
    • Department of Oral and Maxillofacial Surgery, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
    • MURATA MASARU
    • Department of Oral and Maxillofacial Surgery, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
    • OKUBO NAOTO
    • Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University
    • NAGAYASU HIROKI
    • Department of Oral and Maxillofacial Surgery, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
    • AKAZAWA TOSHIYUKI
    • Department of Industrial Technology Research, Hokkaido Research Organization

Abstract

Healthy bone has many physiological microcracks, which may be involved in the release of bone matrix-derived factors and act to accelerate bone-remodeling process. In this study, the mouse parietal bone fragments (5x5x1mm<SUP>3</SUP>) were demineralized by acidic electrolyzed water (AEW: pH2.7) or distilled water (DW: pH5.2) at 120W and 38KHz for 20 min. Each bone was implanted into subcutaneous tissue of 10 week-old male nude mouse, and explanted at 4 and 6 weeks. AEW-bone showed clear enlargement and union of cracks on SEM. AEW-bone revealed active bone induction over wide areas at 6 weeks, while DW-bone induced new bone in limited area. We concluded that the AEW-bone had better performance in bone induction than the DW-bone. Our micro-damage technique combined with AEW and the ultrasonic irradiation will contribute to improve surface area and 3D structure of the dense bone and promote bone formation in the initial stage for bone remodeling.

Journal

  • Phosphorus Research Bulletin

    Phosphorus Research Bulletin 33(0), 1-6, 2017

    Japanese Association of Inorganic Phosphorus Chemistry

Codes

  • NII Article ID (NAID)
    130005628661
  • Text Lang
    ENG
  • ISSN
    0918-4783
  • Data Source
    J-STAGE 
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