脂質を基軸とした免疫調節  [in Japanese] Immunological Regulation by Bioactive Lipids  [in Japanese]

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Author(s)

    • 武富 芳隆 Taketomi Yoshitaka
    • 公益財団法人東京都医学総合研究所脂質代謝プロジェクト Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science
    • 村上 誠 Murakami Makoto
    • 公益財団法人東京都医学総合研究所脂質代謝プロジェクト|東京大学大学院医学系研究科疾患生命工学センター|日本医療研究開発機構(AMED)CREST Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science|Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo|AMED-CREST, Japan Agency for Medical Research and Development

Abstract

 Mast cells originate from hematopoietic stem cells and undergo terminal maturation in the extravascular tissues, in which they are ultimately resident. Mast maturation, phenotype, and function are dictated by the local microenvironment, which has a significant influence on the ability of mast cells to recognize and respond to stimuli. Activation of mast cells can lead to the release of three distinct classes of mediators, including preformed mediators stored in secretory granules, newly transcribed cytokines and chemokines, and <i>de novo</i>-synthesized bioactive lipid mediators. It is currently recognized that bioactive lipids such as arachidonic acid metabolites (prostaglandins and leukotrienes) released from mast cells modulate innate and adaptive immune responses both directly and indirectly through communication with other microenvironmental immune cells or stroma cells. Moreover, mast cells express a variety of lipid receptors and, if activated by bioactive lipids such as arachidonic acid, ω3 fatty acids, lysophospholipids, and their metabolites, can alter the release and production of other mediators including histamine, cytokines, and chemokines, and thereby alter homeostatic or pathophysiological responses. This review focuses on newly identified functional aspects of bioactive lipids with regard to their immune regulation and functional outcomes in both homeostasis and allergic disease.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 137(5), 503-515, 2017

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130005631393
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    028198335
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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