Iron-catalyzed Methylation of Arylboron Compounds with Iodomethane

• Nakajima Sho

  International Research Center for Elements Science (IRCELS), Institute for Chemical Research, Kyoto University Department of Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University

• Takaya Hikaru

  International Research Center for Elements Science (IRCELS), Institute for Chemical Research, Kyoto University Department of Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University

• Nakamura Masaharu

  International Research Center for Elements Science (IRCELS), Institute for Chemical Research, Kyoto University Department of Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University

Abstract

The iron-catalyzed methylation of arylboron compounds has been developed for the first time using iodomethane (CH₃I) as the electrophile. In the presence of catalytic amounts of an iron–bisphosphine complex and MgBr₂, Suzuki–Miyaura-type cross-coupling reactions of CH₃I with various arylboron compounds proceed smoothly under mild conditions to afford the corresponding methylated aromatic compounds in good yields.

Journal

• Chemistry Letters

  Chemistry Letters 46 (5), 711-714, 2017

  The Chemical Society of Japan

Keywords

• Iron catalyst
• Cross-coupling reaction
• Methylation

Details

• CRID: 1390001204589581056
• NII Article ID: 130005655702
• DOI: 10.1246/cl.170079
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://www.journal.csj.jp/doi/pdf/10.1246/cl.170079
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed