Click Reaction Based on the Biosynthesis of Firefly Luciferin

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Author(s)

Abstract

<p>Novel click chemistry was developed based on the biosynthetic process of firefly luciferin, which includes an ideal coupling of a cyanothiazole residue with cysteine. Among various biomimetic couplings of nitriles with cysteine derivatives, the approach using 4-cyanopyridine and cysteine methyl ester provided a very rapid and quantitative conversion to the corresponding thiazole without any metal catalyst at room temperature.</p>

Journal

  • Chemistry Letters

    Chemistry Letters 46(5), 753-755, 2017

    The Chemical Society of Japan

Codes

  • NII Article ID (NAID)
    130005655715
  • Text Lang
    ENG
  • ISSN
    0366-7022
  • Data Source
    J-STAGE 
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