MLL 関連ALL におけるneural-glial antigen 2 （NG2） 抗原使用の 有用性について

DOI

書誌事項

タイトル別名
  • Regarding the utility of the neural-glial antigen 2 (NG2) in MLL-related ALL

この論文をさがす

抄録

<p>We have recognized the appearance of NG2 antigen in MLL rearrangement-positive ALL. However, it is not clear why NG2 antigen appears in MLL rearrangement-positive ALL. The appearance of NG2 is not distinctive, but it is believed to be useful in MRD detection of MLL rearrangement-positive ALL. Using NG2, we are able to confirm the suspected connection with MLL-related ALL (case 1). And we tried to track the course of MRD in the ALL case (case 2). B cellprecursor acute lymphoblastic leukemia (BCPALL) was initially suspected in case 1. However, positive results for CD79a, CD19 and negative results for CD66c led us to use chondroitin sulfate proteoglycan-type neural-glial antigen 2 antibody (NG2 antibody), with a focus on negative CD10, positive CD15 and partially positive CD34 findings. Positive findings for NG2 confirmed the case 1 as mixed lineage leukemia (MLL)-related ALL. In addition, we confirmed the activity of an idioblast rate by visual observation and the positive rate of the MLL split signal. Tracking of the NG2 positive rate in the course of ALL was effective for the detection of MRD in the case 2.</p>

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ