乳がん溶骨型転移による骨基質配向性低下  [in Japanese] Impaired Bone Matrix Alignment Induced by Breast Cancer Metastasis  [in Japanese]

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Author(s)

    • 関田 愛子 Sekita Aiko
    • 大阪大学大学院工学研究科マテリアル生産科学専攻 Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
    • 松垣 あいら Matsugaki Aira
    • 大阪大学大学院工学研究科マテリアル生産科学専攻 Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
    • 中野 貴由 Nakano Takayoshi
    • 大阪大学大学院工学研究科マテリアル生産科学専攻 Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University

Abstract

<p>Bone matrix exhibits highly anisotropic features derived from collagen/apatite orientation, that determine the mechanical function of bone tissue. Breast cancer is highly metastatic to bone tissue and causes osteolytic lesions through osteoclast activation. Nevertheless, the effects of osteoclast activation induced by cancer bone metastasis on bone microstructure, a notable aspect of the bone quality, remains uncertain. In the present study, the effects of osteolytic bone metastasis on the anisotropic microstructure of the bone matrix, particularly the integrity of collagen fibril orientation was investigated. Interestingly, hyperactivation of osteoclasts was induced by osteolytic breast cancer cells both <i>in vivo</i> and <i>in vitro</i>. The cancer cells-derived conditioned medium induced an increased number of nuclei and more specific podosome structures in osteoclasts. These results indicate the resorptive capacity of a single osteoclast was abnormally upregulated in the cancer-mediated environment, causing a geometrical aberration in resorption cavities. Histological studies on mouse femurs with metastasis of breast cancer MDA-MB-231 cells revealed that the osteoclasts in the metastatic bone were abnormally large and they generated resorption cavities that are irregular both in size and in shape. Notably, collagen matrix in newly formed bone in the metastatic bone exhibited a significantly disorganized architecture.</p>

Journal

  • Journal of the Japan Institute of Metals and Materials

    Journal of the Japan Institute of Metals and Materials 81(6), 308-314, 2017

    The Japan Institute of Metals and Materials

Codes

  • NII Article ID (NAID)
    130005678932
  • NII NACSIS-CAT ID (NCID)
    AN00062446
  • Text Lang
    JPN
  • ISSN
    0021-4876
  • NDL Article ID
    028305753
  • NDL Call No.
    Z17-314
  • Data Source
    NDL  J-STAGE 
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