Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women

• Kajikawa Masato

  Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital

• Oda Nozomu

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Kishimoto Shinji

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Maruhashi Tatsuya

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Iwamoto Yumiko

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Iwamoto Akimichi

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Matsui Shogo

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Aibara Yoshiki

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Mohamad Yusoff Farina Binti

  Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

• Hidaka Takayuki

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Kihara Yasuki

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Chayama Kazuaki

  Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Goto Chikara

  Department of Physical Therapy, Hiroshima International University

• Noma Kensuke

  Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

• Nakashima Ayumu

  Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

• Taguchi Akira

  Department of Oral and Maxillofacial Radiology, Matsumoto Dental University

• Higashi Yukihito

  Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

抄録

Background:Osteoporosis and cardiovascular disease are major public health problems. A number of clinical studies have shown a link between osteoporosis and cardiovascular disease, but there is no information on the associations of risk of osteoporotic fracture with vascular function and vascular structure. Methods and Results:The risk of major osteoporotic fracture was calculated using the World Health Organization fracture risk assessment tool (FRAX); vascular function was assessed using flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID), and vascular structure was assessed on brachial artery intima-media thickness (IMT) in 414 subjects (241 men and 173 women) who underwent health examinations. On univariate regression, FRAX was negatively correlated with FMD (total, r=–0.16, P<0.001; men, r=–0.19, P=0.003; women, r=–0.25, P<0.001) and NID (total, r=–0.22, P<0.001; men, r=–0.19, P=0.003; women, r=–0.30, P<0.001) and was positively correlated with brachial artery IMT (total, r=0.12, P=0.02; men, r=0.22, P<0.001; women, r=0.33, P<0.001). On multivariate analysis FRAX remained an independent predictor of FMD, NID, and brachial artery IMT in both men and women. Conclusions:Increase in the risk of osteoporotic fracture evaluated on FRAX is associated with vascular dysfunction and abnormal vascular structure in both men and women. Osteoporosis should be monitored in order to reduce the risk of cardiovascular events.

収録刊行物

• Circulation Journal

  Circulation Journal 81 (6), 862-869, 2017

  一般社団法人 日本循環器学会

キーワード

• Atherosclerosis
• Brachial artery intima-media thickness
• Risk of osteoporotic fracture
• Vascular function

詳細情報

• CRID: 1390282680084745856
• NII論文ID: 130005679608
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-16-1236
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 028184526
• PubMed: 28228610
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028184526
• Web Site: https://www.jstage.jst.go.jp/article/circj/81/6/81_CJ-16-1236/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017384065
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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