Mechanisms of Left Ventricular Dysfunction Assessed by Layer-Specific Strain Analysis in Patients With Repaired Tetralogy of Fallot

• Yamada Mariko

  Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine

• Takahashi Ken

  Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine

• Kobayashi Maki

  Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine

• Yazaki Kana

  Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine

• Takayasu Hirobumi

  Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine

• Akimoto Katsumi

  Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine

• Kishiro Masahiko

  Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine

• Inage Akio

  Department of Pediatric Cardiology, Sakakibara Heart Institute

• Yoshikawa Tadahiro

  Department of Pediatric Cardiology, Sakakibara Heart Institute

• Park In-Sam

  Department of Pediatric Cardiology, Tokyo Women’s Medical University

• Nakanishi Keisuke

  Department of Cardiovascular Surgery, Juntendo University Faculty of Medicine

• Kawasaki Shiori

  Department of Cardiovascular Surgery, Juntendo University Faculty of Medicine

• Shimizu Toshiaki

  Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine

抄録

Background:Left ventricular (LV) dysfunction in patients with repaired tetralogy of Fallot (rTOF) is an important risk factor for adverse outcomes. The aim of this study was to assess the details and time course of such LV dysfunction using layer-specific strain analysis by echocardiography. Methods and Results:The 66 patients with rTOF (mean age, 16.3±9.3 years) were divided into 3 groups (T1: 4–10 years, T2: 11–20 years, T3: 21–43 years), and 113 controls of similar age (mean age, 17.2±9.3 years) were divided into 3 corresponding groups (C1, C2, and C3). Layer-specific longitudinal strain (LS) and circumferential strain (CS) of 3 myocardial layers (endocardial, midmyocardial, and epicardial) were determined by echocardiography. Basal and papillary endocardial CS values were decreased in T1 compared with C1. With the exception of papillary epicardial CS, basal/papillary CS and LS of all 3 layers decreased in T2 compared with C2. Excepting papillary epicardial CS, all other values were decreased in T3 compared with C3. Conclusions:Potential myocardial damage was found in the endocardium at the basal and papillary levels of the LV in young patients with rTOF, extending from the endocardium to the epicardium and from the base to the apex. This is the possible time course of LV dysfunction in patients with rTOF.

収録刊行物

• Circulation Journal

  Circulation Journal 81 (6), 846-854, 2017

  一般社団法人 日本循環器学会

キーワード

• Echocardiography
• Layer-specific strain
• Myocardial deformation
• Tetralogy of Fallot

詳細情報

• CRID: 1390001205108040320
• NII論文ID: 130005679612
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-16-1162
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 028184332
• PubMed: 28260735
• Web Site: http://id.ndl.go.jp/bib/028184332
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028184332
• Web Site: https://www.jstage.jst.go.jp/article/circj/81/6/81_CJ-16-1162/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017384063
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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