Association of Toll-Like Receptor 4 on Human Monocyte Subsets and Vulnerability Characteristics of Coronary Plaque as Assessed by 64-Slice Multidetector Computed Tomography

• Ozaki Yuichi

  Department of Cardiovascular Medicine, Wakayama Medical University

• Imanishi Toshio

  Department of Cardiovascular Medicine, Wakayama Medical University Department of Cardiovascular Medicine, Hidaka General Hospital

• Hosokawa Seiki

  Department of Cardiovascular Medicine, Wakayama Medical University

• Nishiguchi Tsuyoshi

  Department of Cardiovascular Medicine, Wakayama Medical University

• Taruya Akira

  Department of Cardiovascular Medicine, Wakayama Medical University

• Tanimoto Takashi

  Department of Cardiovascular Medicine, Wakayama Medical University

• Kuroi Akio

  Department of Cardiovascular Medicine, Wakayama Medical University

• Yamano Takashi

  Department of Cardiovascular Medicine, Wakayama Medical University

• Matsuo Yoshiki

  Department of Cardiovascular Medicine, Wakayama Medical University

• Ino Yasushi

  Department of Cardiovascular Medicine, Wakayama Medical University

• Kitabata Hironori

  Department of Cardiovascular Medicine, Wakayama Medical University

• Kubo Takashi

  Department of Cardiovascular Medicine, Wakayama Medical University

• Tanaka Atsushi

  Department of Cardiovascular Medicine, Wakayama Medical University

• Akasaka Takashi

  Department of Cardiovascular Medicine, Wakayama Medical University

抄録

Background:Although Toll-like receptor 4 (TLR-4) is involved in monocyte activation in patients with accelerated forms of atherosclerosis, the relationship between the expression of TLR-4 on circulating monocytes and coronary plaque vulnerability has not previously been evaluated. We investigated this relationship using 64-slice multidetector computed tomography (MDCT) in patients with stable angina pectoris (SAP). Methods and Results:We enrolled 65 patients with SAP who underwent MDCT. Three monocyte subsets (CD14⁺⁺CD16⁻, CD14⁺⁺CD16⁺, and CD14⁺CD16⁺) and expression of TLR-4 were measured by flow cytometry. Intracoronary plaques were assessed by 64-slice MDCT. We defined vulnerability of intracoronary plaques according to the presence of positive remodeling (remodeling index >1.05) and/or low CT attenuation (<35 HU). The circulating CD14⁺⁺CD16⁺monocytes more frequently expressed TLR-4 than CD14⁺⁺CD16⁻and CD14⁺CD16⁺monocytes (P<0.001). The relative proportion of the expression of TLR-4 on CD14⁺⁺CD16⁺monocytes was significantly greater in patients with vulnerable plaque compared with those without (10.4 [4.1–14.5] % vs. 4.5 [2.8–7.8] %, P=0.012). In addition, the relative proportion of TLR-4 expression on CD14⁺⁺CD16⁺monocytes positively correlated with the remodeling index (r=0.28, P=0.025) and negatively correlated with CT attenuation value (r=−0.31, P=0.013). Conclusions:Upregulation of TLR-4 on CD14⁺⁺CD16⁺monocytes might be associated with coronary plaque vulnerability in patients with SAP.

収録刊行物

• Circulation Journal

  Circulation Journal 81 (6), 837-845, 2017

  一般社団法人 日本循環器学会

キーワード

• Monocytes
• Multidetector computed tomography (MDCT)
• Plaque vulnerability
• Toll-like receptor 4

詳細情報

• CRID: 1390282680084624000
• NII論文ID: 130005679700
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-16-0688
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 028184287
• PubMed: 28344199
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028184287
• Web Site: https://www.jstage.jst.go.jp/article/circj/81/6/81_CJ-16-0688/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017384062
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可