放射光X線CTによる錠剤内密度分布の測定

• 髙山 幸三

  星薬科大学薬剤学教室

• 乙黒 沙織

  星薬科大学薬剤学教室

• 岡田 信人

  星薬科大学薬剤学教室

• 星野 真人

  公益財団法人高輝度光科学研究センター

• 八木 直人

  公益財団法人高輝度光科学研究センター

• 小幡 誉子

  星薬科大学薬剤学教室

書誌事項

タイトル別名

• Determination of Density Distribution of Tablets Using Synchrotron X-ray Computed Tomography
• ホウシャコウ Xセン CT ニ ヨル ジョウザイ ナイミツド ブンプ ノ ソクテイ

抄録

 The purpose of this study was to determine the density distribution of scored and round-faced tablets using synchrotron X-ray computed tomography. The tablets were made by direct compression of standard formulations. The density distribution of scored flat-faced tablets was uniform in the whole cross-sectional image. However, the tablet formulated using microcrystalline cellulose (MCC) was very dense at the tip of the score only. It is caused by the poor fluidity of MCC particles. In the case of round-faced tablets, the density in the central section of the tablet was relatively low, compared with those of peripheral areas. These observations correlated well with the results obtained by the finite element method simulation using appropriate material models.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 137 (6), 757-762, 2017-06-01

  公益社団法人 日本薬学会

キーワード

• X-ray computed tomography
• density distribution
• scored tablet
• round-faced tablet

詳細情報

• CRID: 1390282681193634688
• NII論文ID: 130005685955
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.16-00271
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 028310226
• PubMed: 28566580
• Web Site: http://id.ndl.go.jp/bib/028310226
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028310226
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/137/6/137_16-00271/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017265346
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可