Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications

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  • Tanaka Tomohiro
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Sawamoto Yasuhiro
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Aoki Shin
    Faculty of Pharmaceutical Sciences, Tokyo University of Science Division of Medical-Science-Engineering Cooperation, Research Institute for Science and Technology, Tokyo University of Science Imaging Frontier Center, Resarch Institute for Science and Technology, Tokyo University of Science

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  • Highlighted Paper selected by Editor-in-Chief : Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications

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Abstract

<p>Sulfoquinovosyl acylpropanediol (SQAP), a chemically modified analogue of sulfoquinovosyl acylglycerol (SQAG) that occurs in sea algae, has been reported to show a variety of biological activities, including accumulation in tumor cells and the inhibition of tumor cell growth. We report herein on a new concise and versatile synthesis of SQAP itself and derivatives bearing iodoaryl groups and boronclusters. This method should be useful for the design and synthesis of SQAG/SQAP derivatives for diagnosis and the treatment of cancer and related diseases.</p>

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