Anti-stress Effect of Green Tea with Lowered Caffeine on Humans: A Pilot Study
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- Unno Keiko
- Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka Tea Science Center, Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka
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- Yamada Hiroshi
- Division of Drug Evaluation & Informatics, School of Pharmaceutical Sciences, University of Shizuoka
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- Iguchi Kazuaki
- Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka
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- Ishida Hitoshi
- Medicinal Chemistry of Natural Products, School of Pharmaceutical Sciences, University of Shizuoka
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- Iwao Yasunori
- Pharmaceutical Engineering Laboratory, School of Pharmaceutical Sciences, University of Shizuoka
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- Morita Akio
- Department of Functional Plant Physiology, Faculty of Agriculture, Shizuoka University
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- Nakamura Yoriyuki
- Tea Science Center, Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka
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<p>Theanine, an amino acid in tea, has significant anti-stress effects on animals and humans. However, the effect of theanine was blocked by caffeine and gallate-type catechins, which are the main components in tea. We examined the anti-stress effect of green tea with lowered caffeine, low-caffeine green tea, on humans. The study design was a single-blind group comparison and participants (n=20) were randomly assigned to low-caffeine or placebo tea groups. These teas (≥500 mL/d), which were eluted with room temperature water, were taken from 1 week prior to pharmacy practice and continued for 10 d in the practice period. The participants ingested theanine (ca. 15 mg/d) in low-caffeine green tea. To assess the anxiety of participants, the state-trait anxiety inventory test was used before pharmacy practice. The subjective stress of students was significantly lower in the low-caffeine-group than in the placebo-group during pharmacy practice. The level of salivary α-amylase activity, a stress marker, increased significantly after daily pharmacy practice in the placebo-group but not in the low-caffeine-group. These results suggested that the ingestion of low-caffeine green tea suppressed the excessive stress response of students. This study was registered at the University Hospital Medical Information Network (ID No. UMIN14942).</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 40 (6), 902-909, 2017
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679608669824
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- NII論文ID
- 130005688068
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 028198345
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- PubMed
- 28566632
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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