網羅的測定による循環器症例における血清IgG4値の検討  [in Japanese] Prevalence of Elevated Serum IgG4 Level among Patients Diagnosed or Suspected with Cardiovascular Disorders  [in Japanese]

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Abstract

<p>IgG4関連疾患は,心血管組織においても存在が報告されている。今回,循環器症例を対象に,網羅的に血清IgG4値を測定した。循環器内科入院の477例,心電図同期CT施行の401例のうち,IgG4高値(135 mg/dL以上)を,それぞれ,23例(4.8%),17例(4.2%)に認めた。IgG4高値のみでは,循環器症例におけるIgG4関連疾患の診断根拠としては不充分であると考えられた。</p>

<p>Immunoglobulin G4 (IgG4)-related disease, that is characterized by the elevation of circulating IgG4 level and the tissue-infiltration of IgG4-positive plasma cells, can target the cardiovascular tissue, although the diagnosis of IgG4-related cardiovascular lesion is not easy owing to the substantial risk for the tissue sampling. We herein examined the serum IgG4 levels among cardiac patients. In patients who were admitted to the cardiology department (n=477) and those who underwent computed tomography coronary artery angiography (n=401), elevated serum IgG4 level (≥135 mg/dL) was found 23 (4.8%) and 17 (4.2%), respectively. However, among those with elevated serum IgG4, only two patients could be clinicopathologically diagnosed with IgG4-related disease. Cardiovascular organ involvement may aggravate the prognosis of IgG4-related disease, which in general not life-threatening. Considering that the non-negligible prevalence of high IgG4 level among cardiac patients who were not diagnosed with IgG4-related disease, however, physicians should no count too much on the serum IgG4 levels for the diagnosis of IgG4-related cardiovascular lesions, especially when histopathologic findings are not available, or when other-tissue involvement of IgG4-related disease is not apparent.</p>

Journal

  • The Journal of Japanese College of Angiology

    The Journal of Japanese College of Angiology 57(6), 91-98, 2017

    Japanese College of Angiology

Codes

  • NII Article ID (NAID)
    130005696953
  • Text Lang
    JPN
  • ISSN
    0387-1126
  • Data Source
    J-STAGE 
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