Body mass index and stroke incidence in Japanese community residents: The Jichi Medical School (JMS) Cohort Study

• Kawate Nami

  Graduate School of Saitama Prefectural University

• Kayaba Kazunori

  Graduate School of Saitama Prefectural University

• Hara Motohiko

  Graduate School of Saitama Prefectural University

• Kotani Kazuhiko

  Department of Clinical Laboratory Medicine, Department of Public Health, Jichi Medical University

• Ishikawa Shizukiyo

  Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University

Abstract

Background: High body mass index (BMI) has been reported as a risk factor for cardiovascular events in Western countries, while low BMI has been reported as a risk factor for cardiovascular death in Asian countries, including Japan. Although stroke is a major cause of death and disability in Japan, few cohort studies have examined the association between BMI and stroke incidence in Japan. This study aimed to examine the association between BMI and stroke incidence using prospective data from Japanese community residents. Methods: Data were analyzed from 12,490 participants in the Jichi Medical School Cohort Study. Participants were categorized into five BMI groups: ≤18.5, 18.6–21.9, 22.0–24.9, 25.0–29.9, and ≥30.0 kg/m². Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazard model. The group with a BMI of 22.0–24.9 kg/m² was used as the reference category. Results: During mean follow-up of 10.8 years, 395 participants (207 men and 188 women) experienced stroke, including 249 cerebral infarctions and 92 cerebral hemorrhages. Men with a BMI ≤18.5 kg/m² (HR 2.11; 95% CI, 1.17–3.82) and women with a BMI ≥30.0 kg/m² (HR 2.25; 95% CI, 1.28–5.08) were at significantly higher risk for all-stroke. Men with a BMI ≤18.5 kg/m² were at significantly higher risk for cerebral infarction (HR 2.15; 95% CI, 1.07–4.33). Conclusions: The association between BMI and stroke incidence observed in this population was different than those previously reported: low BMI was a risk factor for all-stroke and cerebral infarction in men, while high BMI was a risk factor for all-stroke in women.

Journal

• Journal of Epidemiology

  Journal of Epidemiology 27 (7), 325-330, 2017

  Japan Epidemiological Association

Keywords

• Body mass index
• Community-based cohort study
• Stroke
• Japanese population
• Sex difference

Details

• CRID: 1390001204475642368
• NII Article ID: 130005709466
• DOI: 10.1016/j.je.2016.08.007
• ISSN: 13499092
• ISSN: 09175040
• Web Site: http://api.elsevier.com/content/article/PII:S0917504017300205?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S0917504017300205?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2018114753
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed