Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages.

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Author(s)

    • Komohara Yoshihiro
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Nosaka Kisato
    • Department of Hematology, Graduate School of Medical Sciences, Kumamoto University
    • Shimosaki Shunsuke
    • Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, University of Miyazaki
    • Morishita Kazuhiro
    • Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, University of Miyazaki
    • Matsuoka Masao
    • Department of Hematology, Graduate School of Medical Sciences, Kumamoto University|Laboratory of Virus Control, Institute for Virus Research, Kyoto University
    • Wakayama Tomohiko
    • Department of Histology, Graduate School of Medical Sciences, Kumamoto University
    • Takeya Motohiro
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Ma Chaoya
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Yano Hiromu
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Pan Cheng
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Horlad Hasita
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Saito Yoichi
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Ohnishi Koji
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Fujiwara Yukio
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
    • Okuno Yutaka
    • Department of Hematology, Graduate School of Medical Sciences, Kumamoto University

Abstract

<p>Cell adhesion molecule 1 (CADM1) is a cell adhesion molecule that is expressed in brain, liver, lung, testis, and some kinds of cancer cells including adult T-cell leukemia/lymphoma (ATLL). Recent studies have indicated the involvement of CADM1 in cell-cell contact between cytotoxic T-lymphocytes and virus infected cells. We previously reported that cell-cell interaction between lymphoma cells and macrophages induces lymphoma cell proliferation. In the present study, we investigated whether CADM1 is associated with cell-cell interaction between several human lymphoma cell lines and macrophages.</p><p>CADM1 expression was observed in the ATLL cell lines, ATN-1, ATL-T, and ATL-35T, and in the B cell lymphoma cell lines, TL-1, DAUDI, and SLVL, using western blotting. Significant cell-cell interaction between macrophages and ATN-1, ATL-T, ATL-35T and MT-2, DAUDI, and SLVL cells, as assessed by induction of cell proliferation, was observed. Immunohistochemical analysis of human biopsy samples indicated CADM1 expression in 10 of 14 ATLL cases; however, no case of follicular lymphoma or diffuse large B-cell lymphoma was positive for CADM1. Finally, the interaction of macrophages with cells of the CADM1-negative ED ATLL cell line and CADM1-transfected ED cells was tested. However, significant cell-cell interaction between macrophage and CADM1-transfected ED cells was not observed. We conclude that CADM1 was not associated with cell-cell interaction between lymphoma cells and macrophages, although CADM1 may be a useful marker of ATLL for diagnostic procedures.</p>

Journal

  • Journal of Clinical and Experimental Hematopathology

    Journal of Clinical and Experimental Hematopathology 57(1), 15-20, 2017

    The Japanese Society for Lymphoreticular Tissue Research

Codes

  • NII Article ID (NAID)
    130005709559
  • Text Lang
    ENG
  • ISSN
    1346-4280
  • Data Source
    J-STAGE 
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