Histologic Evaluation of Bone Regeneration using Titanium Mesh Prepared by Selective Laser Melting Technique

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  • Yamamoto Kayoko
    Division of Medicine for Function and Morphology of Sensor Organ, Dentistry and Oral Surgery, Osaka Medical College
  • Yamaguchi Seiji
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • Matsushita Tomiharu
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University
  • Mori Shigeo
    AM & Medical Promotion Section, Powder Processing Department, Osaka Yakin Kogyou Co, Ltd
  • Kitagaki Hisashi
    AM & Medical Promotion Section, Powder Processing Department, Osaka Yakin Kogyou Co, Ltd
  • Yoshimura Hitoshi
    Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Divison of Medicine, Faculty of Medical Sciences, University of Fukui
  • Sano Kazuo
    Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Divison of Medicine, Faculty of Medical Sciences, University of Fukui
  • Sunano Akihiro
    Division of Medicine for Function and Morphology of Sensor Organ, Dentistry and Oral Surgery, Osaka Medical College
  • Nakajima Yoichiro
    Division of Medicine for Function and Morphology of Sensor Organ, Dentistry and Oral Surgery, Osaka Medical College
  • Nakano Hiroyuki
    Division of Medicine for Function and Morphology of Sensor Organ, Dentistry and Oral Surgery, Osaka Medical College
  • Ueno Takaaki
    Division of Medicine for Function and Morphology of Sensor Organ, Dentistry and Oral Surgery, Osaka Medical College

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Abstract

<p>Various biochemical researches have been conducted for bone defects in the head, neck and maxillofacial region. Guided Bone Regeneration (GBR), which does not require any graft material, has focused on. However, GBR has been considered to be difficult to be used for critical-sized bone defects. In recent years, it has been made possible to make three-dimensional (3D) structures by additive manufacturing, which titanium (Ti) powders are successively melted and solidified (Selective Laser Melting technique; SLM). Using this technique, Ti devices in various shapes have been made available for practical use. In this study, we used Ti meshes prepared by SLM in a rat calvaria bone defect model, and examined the bone formation process at the bone defect site. Observations of undecalcified ground samples showed that the amount of new bone formation in 2 weeks postoperatively in the SLM-prepared Ti mesh group was significantly greater than that in the control group. This result suggests that SLM-prepared Ti meshes have a high osteogenic potential in vivo.</p>

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