Cytoplasmic ABCG2 and Podoplanin Expression in Oral Squamous Cell Carcinoma Correlates with Lymph Node Metastasis

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  • Liu Han
    Department of Oral Pathology, Dalian Medical University
  • Xia Shilin
    Clinical Laboratory of Integrative Medicine, the First Affiliated Hospital of Dalian Medical University
  • Zhu Lei
    Department of Oral Pathology, Dalian Medical University
  • Li Nan
    Department of Oral Pathology, Dalian Medical University
  • Yang Qian
    Department of Oral Pathology, Dalian Medical University
  • Dong Yan
    Department of Oral Pathology, Dalian Medical University
  • Nakano Keisuke
    Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Nagatsuka Hitoshi
    Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Xiao Jing
    Department of Oral Pathology, Dalian Medical University

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Abstract

<p>The cervical lymph node metastasis of Oral Squamous Cell Carcinoma (OSCC) has been considered to be the main causes of death. The aim of our study was to clarify the expression pattern of ABCG2 and podoplanin in OSCC tissues and corresponding cervical lymph node, and evaluate the diagnostic value of ABCG2 and podoplanin in OSCC for tumorigenesis, histological stage and clinical prognosis. ABCG2 showed a mixed membranous and cytoplasmic pattern of staining in specific regions of stratum corneum and the center of well differentiated cancer nest, while only expressed in cytoplasm of poorly differentiated tumor nests. Podoplanin showed strong staining in LV endothelia, the periphery of well differentiated cancer nests, and tumor stromal fibroblasts surrounding tumor nests. The expression of ABCG2, especially cytoplasmic ABCG2, and podoplanin protein showed significantly higher tendency to lymph node metastasis (P<0.05). Meanwhile, podoplanin positive rate increased with the decreasing degree of histological differentiation (P<0.05). ABCG2 and podoplanin expression pattern is correlated with lymph node metastasis of OSCC. This result suggested that cytoplasmic ABCG2 with podoplanin have clinical potential in reliable molecule diagonsis for OSCC.</p>

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