書誌事項
- タイトル別名
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- Basic research for development of ultrasonic prevention of vascular occlusion
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Background: Reocclusion occurred after various recanalization therapies. In particular, reocclusion was frequently observed immediately after the recombinant tissue-type plasminogen activator (rt-PA) treatment. This is a fatal problem, because anticoagulant therapy is prohibited within 24 hours after the rt-PA treatment. We report the thrombus growth control effect of non-invasive ultrasound (US) in an in vitro clot growth model.<br> Method: A clot was prepared by incubation of citrated human plasma, CaCl2 solution and thrombin at 37°C for 60 min in a latex tube. After incubation, the latex tube was filled with degassed citrated human plasma. The plasma around the clot was irradiated with US in a water bath at 37°C. The US irradiation condition was: transducer size 10 mm, frequency 500 kHz, continuous wave, average intensity 0.32 W/cm2, 30 min. To evaluate the thrombus growth control effect, the clot’s weight was measured before and after US irradiation. <br> Results: The clot’s increased weight was significantly suppressed in the US group compared with the Non-US group (58.3 mg vs. 107.7 mg, p<0.0025). <br> Conclusions: In this study, we showed that the non-invasive US could control the growth of thrombus. This safe and simple US method may be used to prevent the reocclusion after recanalization therapy.
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- Neurosonology:神経超音波医学
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Neurosonology:神経超音波医学 30 (1), 4-7, 2017
一般社団法人日本脳神経超音波学会
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詳細情報 詳細情報について
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- CRID
- 1390001204421642624
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- NII論文ID
- 130005757719
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- ISSN
- 18843336
- 0917074X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 使用不可