<b>CD36 involvement in the olfactory perception of oleic aldehyde, an odour-active volatile compound, in</b><b> mice </b>
-
- LEE Shinhye
- Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
-
- TSUZUKI Satoshi
- Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
-
- AMITSUKA Takahiko
- R&D Center, T. Hasegawa Co., Ltd.
-
- MASUDA Daisaku
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- YAMASHITA Shizuya
- Department of Community Medicine, Osaka University Graduate School of Medicine
-
- INOUE Kazuo
- Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
Bibliographic Information
- Other Title
-
- CD36 involvement in the olfactory perception of oleic aldehyde, an odour-active volatile compound, in mice
Search this article
Abstract
<p>Cluster of differentiation 36 (CD36) is a broadly expressed transmembrane receptor that has multiple ligands. It has been found to occur abundantly on the surface of the olfactory epithelium in mice and postulated to play a role in mammalian olfaction. However, there have been no ethological analyses of the mammalian behaviour showing CD36 involvement in the olfactory perception of a distinct odour-active volatile compound. In this study, we aimed to assess whether mammals perceive oleic aldehyde, an odour-active volatile that serves as a potential CD36 ligand, and if so, whether CD36 is involved in the sensing by following measurements using CD36-knockout mice and their wild-type littermates. In a two-bottle choice test, wild-type mice, but not CD36-knockout mice, discriminated a sucrose solution containing oleic aldehyde from the sucrose solution alone. To assess the importance of the olfactory system in the oleic aldehyde perception, we conducted an exploration test where the animals could rely primarily on the odour of test volatiles for recognition. We found that the wild-type, but not CD36-knockout mice, were aware of the compound. Our results provide behavioural evidence that CD36 plays a role in the perception of specific odour-active volatile compounds in the nasal cavity.</p>
Journal
-
- Biomedical Research
-
Biomedical Research 38 (3), 207-213, 2017
Biomedical Research Press