Thrombolysis-related Multiple Lobar Hemorrhaging in Cerebral Amyloid Angiopathy with Extensive Strictly Lobar Cerebral Microbleeding

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Author(s)

    • Eriguchi Makoto
    • Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Japan
    • Yakushiji Yusuke
    • Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Japan
    • Tanaka Jun
    • Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Japan
    • Hara Hideo
    • Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Japan

Abstract

<p>A hemi-paralyzed 86-year-old man was diagnosed with ischemic stroke and underwent thrombolysis. Pre-thrombolysis brain magnetic resonance imaging revealed extensive strictly lobar cerebral microbleeding (CMB). Post-thrombolytic computed tomography revealed asymptomatic multiple intracerebral hemorrhaging (ICH). His age, CMB topography, and decreased cerebral spinal fluid amyloid-β 40 and 42 levels were compatible with a diagnosis of cerebral amyloid angiopathy (CAA). There is no consensus on the safety of thrombolysis for acute stroke patients with CAA. Patients with CAA might have a higher incidence of thrombolysis-related ICH than those without CAA. </p>

Journal

  • Internal Medicine

    Internal Medicine 56(14), 1907-1910, 2017

    The Japanese Society of Internal Medicine

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