Evaluation of Ligand-Conjugated Polyglycerol Dendrimers as a <small>L</small>-arginine Carrier

• ITAKURA Yukie

  Graduate School of Engineering, Kobe University

• OOYA Tooru

  Graduate School of Engineering, Kobe University

Bibliographic Information

Other Title

• がん細胞指向性リガンドを導入したポリグリセロールデンドリマーのアルギニンデリバリー評価
• ガン サイボウ シコウセイ リガンド オ ドウニュウ シタ ポリグリセロールデンドリマー ノ アルギニンデリバリー ヒョウカ

Abstract

Folic acid (FA) or biotin-conjugated polyglycerol dendrimers (PGD) that are known to tightly bind to L-arginine (Arg) are explored as possible L-arginine carriers. PGD with generation 3 (PGD-G3) was conjugated with FA or biotin by using a condensation reagent, with a 1:1 stoichiometry. Furthermore, cellular uptake studies suggest that FA or biotin-conjugated PGDs can be used as Arg carriers.

Journal

• KOBUNSHI RONBUNSHU

  KOBUNSHI RONBUNSHU 74 (4), 304-310, 2017

  The Society of Polymer Science, Japan

Keywords

• Dendrimer
• Polyglycerol
• Ligands
• Biotin
• Folic Acid
• Arginine
• Cancer Cells

Details

• CRID: 1390001206524933632
• NII Article ID: 130005858725
• NII Book ID: AN00085011
• DOI: 10.1295/koron.2017-0011
• ISSN: 18815685
• ISSN: 03862186
• NDL BIB ID: 028411506
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028411506
• Web Site: https://www.jstage.jst.go.jp/article/koron/74/4/74_2017-0011/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed