Cytokine profile after oral food challenge in infants with food protein-induced enterocolitis syndrome

• Kimura Mitsuaki

  Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital

• Ito Yasunori

  Department of Pediatrics, Faculty of Medicine, University of Toyama

• Shimomura Masaki

  Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital

• Morishita Hideaki

  Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital

• Meguro Takaaki

  Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital

• Adachi Yuichi

  Department of Pediatrics, Faculty of Medicine, University of Toyama

• Seto Shiro

  Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital

抄録

Background: Although food protein-induced enterocolitis syndrome (FPIES) is supposed to be caused by inflammation, the role of cytokines has not yet been clarified. Methods: To elucidate the role of cytokines in the development of symptoms and abnormal laboratory findings at an oral food challenge (OFC), changes in serum cytokine levels were analyzed for 6 OFCs in 4 patients with FPIES. The result of OFC was judged positive if any gastrointestinal (GI) symptoms (vomiting, diarrhea, or bloody stool) were induced. Results: Among 11 cytokines profiled, serum levels of interleukin (IL)-2, IL-5, and IL-8 were clearly increased in all 4 positive OFCs in which elevations of the serum level of C-reactive protein (CRP) and peripheral blood neutrophilia were also seen. The level of serum IL-10 also rose in 2 positive OFCs. Remarkable increases in the serum level of interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), IL-6, and IL-12 were observed in a positive OFC where the serum level of CRP rose markedly (6.75 mg/dL). The serum levels of IL-5 were also elevated in 2 negative OFCs. No apparent specific correlations were found between cytokines and GI symptoms. Conclusions: These results suggest that IL-2 and IL-8 are involved in the antigen-specific immune responses in most patients with FPIES. Further studies are needed to elucidate the significance of these cytokine in the pathogenesis of FPIES.

収録刊行物

• Allergology International

  Allergology International 66 (3), 452-457, 2017

  一般社団法人日本アレルギー学会

キーワード

• Food protein-induced enterocolitis syndrome
• Interleukin-2
• Interleukin-5
• Interleukin-8
• Oral food challenge

詳細情報

• CRID: 1390282679609494656
• NII論文ID: 130005858805
• DOI: 10.1016/j.alit.2016.12.001
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893016301708?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893016301708?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2018093007
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
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