Triterpenoids Isolated from Ziziphus jujuba Enhance Glucose Uptake Activity in Skeletal Muscle Cells

• KAWABATA Kyuichi

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• KITAMURA Kenji

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• IRIE Kazuhiro

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• NARUSE Shoma

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• MATSUURA Tomohiro

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• UEMAE Tomoyuki

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• TAIRA Shu

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• OHIGASHI Hajime

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• MURAKAMI Shigeru

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• TAKAHASHI Masakazu

  Department of Bioscience, Faculty of Biotechnology, Fukui Prefectural University

• KAIDO Yoko

  Searoad Co., Ltd.

• KAWAKAMI Bunsei

  The Hokuriku Industrial Advanced Center

書誌事項

タイトル別名

• Triterpenoids Isolated from <i>Ziziphus jujuba</i> Enhance Glucose Uptake Activity in Skeletal Muscle Cells

抄録

Jujube (Ziziphus jujuba Mill.), a traditional folk medicine and functional food in China and South Korea, is known for its beneficial properties, which include anti-cancer, anti-oxidative, and anti-obesity effects. To assess the anti-hyperglycemic effect of jujube in this study, we investigated the glucose uptake-promoting activity of jujube in rat L6 myotubes. After determining that the jujube extract induces muscle glucose uptake, we identified the following active compounds by bioassay-guided fractionation: betulonic acid, betulinic acid, and oleanonic acid. Ursonic acid, known to be present in jujube, was semi-synthesized from ursolic acid and also observed to enhance glucose uptake. These four triterpenic acids induced glucose uptake in a glucose transporter 4-dependent manner. Comparison experiments of jujube fruits from three countries, namely, China, South Korea, and Japan, revealed that Japanese jujube has a higher content of active triterpenoids and is the most potent enhancer of glucose uptake.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 63 (3), 193-199, 2017

  一般財団法人 学会誌刊行センター

キーワード

• <i>Ziziphus jujuba</i>
• triterpenoids
• skeletal muscle
• glucose uptake
• hyperglycemia

詳細情報

• CRID: 1390001206326293632
• NII論文ID: 130005866046
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.63.193
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 028310181
• PubMed: 28757534
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028310181
• Web Site: https://www.jstage.jst.go.jp/article/jnsv/63/3/63_193/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018038759
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可