Preventive Effects of the Dietary Intake of Medium-chain Triacylglycerols on Immobilization-induced Muscle Atrophy in Rats

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  • Nishimura Shuhei
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
  • Inai Makoto
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
  • Takagi Tetsuo
    Central Research Laboratory, The Nisshin-OilliO Group, Ltd.
  • Nonaka Yudai
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
  • Urashima Shogo
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
  • Honda Kazumitsu
    Central Research Laboratory, The Nisshin-OilliO Group, Ltd.
  • Aoyama Toshiaki
    Central Research Laboratory, The Nisshin-OilliO Group, Ltd.
  • Terada Shin
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo

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<p>Previous studies have shown that medium-chain triacylglycerols (MCTs) exert favorable effects on protein metabolism. This study evaluated the effects of the dietary intake of MCTs on rat skeletal muscle mass and total protein content during casting-induced hindlimb immobilization, which causes substantial protein degradation and muscle atrophy. Rats were fed a standard diet containing long-chain triacylglycerols (LCTs) or MCTs for 3 days and then a unilateral hindlimb was immobilized while they received the same diet. After immobilization for 3, 7, and 14 days, muscle mass and total protein content in immobilized soleus muscle in the LCT-fed rats had markedly decreased compared to the contralateral muscle; however, these losses were partially suppressed in MCT-fed rats. Autophagosomal membrane proteins (LC-I and -II), which are biomarkers of autophagy-lysosome activity, did not differ significantly between the LCT- and MCT-fed rats. In contrast, the immobilization-induced increase in muscle-specific E3 ubiquitin ligase MuRF-1 protein expression in immobilized soleus muscle relative to contralateral muscle was completely blocked in the MCT-fed rats and was significantly lower than that observed in the LCT-fed rats. Collectively, these results indicate that the dietary intake of MCTs at least partly alleviates immobilization-induced muscle atrophy by inhibiting the ubiquitin-proteasome pathway.</p>

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