Analysis of Serum Cholesterol Efflux Capacity in a Minipig Model of Nonischemic Heart Failure
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- Bigazzi Federico
- Fondazione Toscana Gabriele Monasterio
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- Adorni Maria Pia
- Department of Pharmacy, University of Parma
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- Puntoni Mariarita
- CNR Institute of Clinical Physiology
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- Sbrana Francesco
- Fondazione Toscana Gabriele Monasterio
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- Lionetti Vincenzo
- Fondazione Toscana Gabriele Monasterio Laboratory of Medical Science, Institute of Life Sciences, Scuola Superiore Sant'Anna
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- Pino Beatrice Dal
- Fondazione Toscana Gabriele Monasterio
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- Favari Elda
- Department of Pharmacy, University of Parma
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- Recchia Fabio A.
- Laboratory of Medical Science, Institute of Life Sciences, Scuola Superiore Sant'Anna Department of Physiology, Temple University School of Medicine
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- Bernini Franco
- Department of Pharmacy, University of Parma
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- Sampietro Tiziana
- Fondazione Toscana Gabriele Monasterio
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<p>Aim: Circulating levels of high-density lipoprotein cholesterol (HDL-C) are decreased in patients with heart failure (HF). We tested whether HDL-C serum levels are associated with cardiac contractile dysfunction in a minipig HF model.</p><p>Methods: Blood samples were collected from 13 adult male minipigs: 1) before pacemaker implantation, 2) 10 days after surgery, and 3) 3 weeks after high-rate LV pacing. Serum cholesterol efflux capacity (CEC), an index of HDL functionality, was assessed through four mechanisms: ATP Binding Cassette transporter A1 (ABCA1), ATP Binding Cassette transporter G1 (ABCG1), Scavenger Receptor-Class B Type I (SR-BI) and Passive Diffusion (PD).</p><p>Results: HDL-C serum levels significantly decrease in minipigs with HF compared with baseline (p＜0.0001). Serum CEC mediated by PD and SR-BI, but not ABCA1 or ABCG1, significantly decrease in animals with HF (p＜0.05 and p＜0.005, respectively).</p><p>Discussion: HDL-C serum levels and partial serum CEC reduction may play a pathophysiological role in the cardiac function decay sustained by high-rate LV pacing, opening new avenues to understand of the pathogenesis of nonischemic myocardial remodeling.</p>
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 24 (8), 853-862, 2017
一般社団法人 日本動脈硬化学会
