The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice
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- Aizawa Fuka
- Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
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- Ogaki Yoshihiro
- Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
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- Kyoya Natsuki
- Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
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- Nishinaka Takashi
- Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
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- Nakamoto Kazuo
- Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
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- Kurihara Takashi
- Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- Hirasawa Akira
- Department of Genomic Drug Discovery Sciences, Kyoto University
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- Miyata Atsuro
- Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- Tokuyama Shogo
- Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
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Abstract
<p>The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA). This receptor has been the focus of many studies regarding physiological functions of the central nervous system. PUFAs are essential for neuronal development and maintenance of neuronal function; thus, the decrease of PUFAs in the brain is closely related to the induction of psychiatric diseases associated with emotional disorder, such as anxiety, depression, and schizophrenia. However, details of the mechanisms remain unclear. In this study, we investigated changes of maternal and/or emotional behavior caused by a deficiency of GPR40/FFAR1 signaling. GPR40/FFAR1 deficient (FFAR1−/−) female mice exhibited impaired maternal care such as retrieving behaviors and an increased rate of neglect and infanticide when compared to wild type (WT) female mice. Furthermore, FFAR1−/− female mice showed increased time spent in the open arms in an elevated plus maze test, reduction of locomotor activity and social interaction behavior, and decreased sucrose intake, when compared to WT female mice. In conclusion, these findings suggest that PUFAs-GPR40/FFAR1 signaling might function, at least in part, as a regulatory factor of emotional and maternal behavior in mice.</p>
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 40 (8), 1255-1259, 2017
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204631248512
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- NII Article ID
- 130005876328
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 028388414
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- PubMed
- 28769007
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed