Prediction of prognosis of upper-extremity function following stroke-related paralysis using brain imaging

• Nakashima Akira

  Department of Rehabilitation, Juzenkai Hospital, Japan Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Moriuchi Takefumi

  Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan Research Fellow of the Japan Society for the Promotion of Science, Japan

• Mitsunaga Wataru

  Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Yonezawa Takehito

  Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Kataoka Hideki

  Department of Rehabilitation, Nagasaki Memorial Hospital, Japan

• Nakashima Ryusei

  Department of Rehabilitation, Nagasaki Rehabilitation Hospital, Japan

• Koizumi Tetsuji

  Department of Rehabilitation, Juzenkai Hospital, Japan

• Shimizu Tadashi

  Department of Neurosurgery, Juzenkai Hospital, Japan

• Ryu Nobutoshi

  Department of Neurosurgery, Juzenkai Hospital, Japan

• Higashi Toshio

  Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan

Abstract

[Purpose] Diffusion tensor imaging (DTI) has attracted attention as a method for determining prognosis following paralysis after stroke. However, DTI can assess the degree of damage to the corticospinal tract but cannot evaluate other brain regions. In this study, we examined in detail the prognosis of upper-limb function of the paralyzed side following stroke, using DTI and voxel-based morphometry (VBM). [Subjects and Methods] We studied 17 consecutive patients diagnosed with stroke, including hemorrhagic and ischemic types, who exhibited hemiparesis and were treated in our hospital. DTI and VBM were performed 14 days after admission. Outcome measurements that assessed upper limb function were Fugl-Meyer Assessment (FMA) and Motor Activity Log (MAL), which were applied after 3 months. [Results] The fractional anisotropy ratio of the bilateral cerebral peduncles (rFA) was significantly correlated with FMA, amount of use, and quality of movement 3 months after stroke. The precentral gyrus significantly degenerated as compared with the control group for a case with notable motor paralysis, for which rFA was high. [Conclusion] We suggest it may be possible to predict recovery of upper limb function following stroke by combining DTI and VBM visualization methods.

Journal

• Journal of Physical Therapy Science

  Journal of Physical Therapy Science 29 (8), 1438-1443, 2017

  The Society of Physical Therapy Science

Keywords

• Upper-extremity function
• Diffusion tensor imaging
• Voxel-based morphometry

Details

• CRID: 1390282679307651712
• NII Article ID: 130005966752
• DOI: 10.1589/jpts.29.1438
• ISSN: 21875626
• ISSN: 09155287
• Web Site: https://www.jstage.jst.go.jp/article/jpts/29/8/29_jpts-2017-224/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018162090
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed