Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population ― The Hisayama Study ―

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Author(s)

Abstract

<p><b><i>Background:</i></b>Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations.</p><p><b><i>Methods and Results:</i></b>We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002–2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)<sub>2</sub>D levels (HR 1.54 [95% confidence interval, 1.18–2.01] for the lowest quartile, 1.31 [0.99–1.73] for the 2nd quartile, 0.94 [0.70–1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)<sub>2</sub>D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m<sup>2</sup>than in those with eGFR ≥60 mL/min/1.73 m<sup>2</sup>; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04).</p><p><b><i>Conclusions:</i></b>The findings suggested that a lower serum 1,25(OH)<sub>2</sub>D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)<sub>2</sub>D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.</p>

Journal

  • Circulation Journal

    Circulation Journal 81(9), 1315-1321, 2017

    The Japanese Circulation Society

Codes

  • NII Article ID (NAID)
    130006003854
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • ISSN
    1346-9843
  • NDL Article ID
    028460822
  • NDL Call No.
    Z54-B860
  • Data Source
    NDL  J-STAGE 
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