Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population　― The Hisayama Study ―

• Umehara Kaoru

  Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University

• Mukai Naoko

  Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University

• Hata Jun

  Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University

• Hirakawa Yoichiro

  Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University

• Ohara Tomoyuki

  Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University

• Yoshida Daigo

  Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University

• Kishimoto Hiro

  Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University

• Kitazono Takanari

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Hoka Sumio

  Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University

• Kiyohara Yutaka

  Hisayama Research Institute For Lifestyle Diseases

• Ninomiya Toshiharu

  Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University

Abstract

Background:Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations. Methods and Results:We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)₂D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002–2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)₂D levels (HR 1.54 [95% confidence interval, 1.18–2.01] for the lowest quartile, 1.31 [0.99–1.73] for the 2nd quartile, 0.94 [0.70–1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)₂D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m²than in those with eGFR ≥60 mL/min/1.73 m²; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04). Conclusions:The findings suggested that a lower serum 1,25(OH)₂D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)₂D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.

Journal

• Circulation Journal

  Circulation Journal 81 (9), 1315-1321, 2017

  The Japanese Circulation Society

Keywords

• Cardiovascular death
• General population
• Prospective cohort study
• Respiratory infection death
• Vitamin D

Details

• CRID: 1390282680085187584
• NII Article ID: 130006003854
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-16-0954
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 028460822
• PubMed: 28428487
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028460822
• Web Site: https://www.jstage.jst.go.jp/article/circj/81/9/81_CJ-16-0954/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018114852
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed