80歳一般地域住民における糖尿病の生命予後への影響  [in Japanese] The Impact of Diabetes Mellitus on Mortality in Japanese Individuals Who Are 80 Years Old in the General Population  [in Japanese]

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Author(s)

    • 園木 一男 Sonoki Kazuo
    • 九州歯科大学歯学部口腔保健学科学際教育推進ユニット Unit for Promotion of Interdisciplinary Education and Research, School of Oral Health Science, Kyushu Dental University
    • 秋房 住郎 Akifusa Sumio
    • 九州歯科大学歯学部口腔保健学科地域・多職種連携教育ユニット Unit of Education on Healthcare Team, School of Oral Health Science, Kyushu Dental University
    • 福原 正代 Fukuhara Masayo
    • 九州歯科大学歯学部歯学科総合内科学分野 Division of General Internal Medicine, Department of Health Promotion, Kyushu Dental University
    • 邵 仁浩 Soh Inho
    • 九州歯科大学歯学部歯学科地域健康開発歯学分野 Division of Community Oral Health Development, Department of Health Promotion, Kyushu Dental University
    • 粟野 秀慈 Awano Shuji
    • 九州歯科大学歯学部歯学科クリニカルクラークシップ開発学分野 Department of Clinical Education Development and Research, School of Dentistry, Kyushu Dental University
    • 安細 敏弘 Ansai Toshihiro
    • 九州歯科大学歯学部歯学科地域健康開発歯学分野 Division of Community Oral Health Development, Department of Health Promotion, Kyushu Dental University

Abstract

<p>日本人一般地域住民における80歳高齢者の生命予後に対する糖尿病の影響を明らかにするため,平成10年に内科・歯科検診を受診した福岡県北九州市とその近郊に在住する80歳666名の4年間および12年間の生存期間と死因(全死亡,肺炎死,循環器死,悪性腫瘍死)を糖尿病群74名(男性35名,女性39名),非糖尿病群592名(男性231名,女性361名)で比較した.12年間の追跡調査では,糖尿病群の生存率は全死亡と肺炎死で非糖尿病群より低かった.Cox回帰分析では,非糖尿病群に比し4年間で糖尿病群の全死亡が1.76倍,肺炎死が3.26倍,12年間で全死亡が1.84倍,肺炎死が2.97倍,悪性腫瘍死が2.42倍高かった.血糖コントロール不良群は非糖尿病群に比し4年間で全死亡のリスク,12年間で全死亡,肺炎死,循環器死のリスクが高かった.糖尿病は80歳高齢者においても予後規定因子である可能性が示唆された.</p>

<p>To investigate the influence of diabetes mellitus on mortality in Japanese individuals who are 80 years old in the general population, we compared 74 diabetic subjects with 592 non-diabetic subjects who received the general and dental health examinations in Fukuoka prefecture in 1998 and who were followed-up for 4 years and 12 years after the baseline examination to collect data and information on the cause of death. The cumulative survival rate during the 12-year follow-up period from all-cause mortality and pneumonia mortality in the diabetic group was lower than that in the non-diabetic group. A Multivariate Cox regression analysis revealed that the risk of mortality in the diabetic group was higher than that in the non-diabetic group (1.76-fold for 4 years and 1.84-fold for 12 years). Notably, the risk of pneumonia mortality in the diabetic group was 3.26-fold and 2.97-fold higher than that in the non-diabetic group at 4 years and 12 years, respectively. During the 12 year follow-up period, the cancer mortality in the diabetic group was 2.42-fold higher than that in the non-diabetic group. In the poor glycemic control group, all-cause mortality at 4 years and all-cause mortality, pneumonia mortality, and cardiovascular disease mortality at 12 years were higher in comparison to the non-diabetic group. Diabetes mellitus increased the risk of mortality, especially pneumonia mortality, even in people who are 80 years old.</p>

Journal

  • Journal of the Japan Diabetes Society

    Journal of the Japan Diabetes Society 60(8), 515-523, 2017

    THE JAPAN DIABETES SOCIETY

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