バクテリアにおけるヘムの獲得と輸送の構造生物学

• 杉本 宏

  理化学研究所 放射光科学総合研究センター

書誌事項

タイトル別名

• Structural Biology of the Bacterial Heme Acquisition and Transport Systems
• バクテリア ニ オケル ヘム ノ カクトク ト ユソウ ノ コウゾウ セイブツガク

抄録

Iron is an essential element for almost all living organism as it serves as a catalytic center for redox and metabolic reactions in many enzymes. Bacterial pathogens have evolved the efficient systems for the heme acquisition to survive in the host tissues and body fluids, because the heme is a rich source of iron. Pathogens grab the heme from the host hemoproteins and import it into cytoplasm by using many proteins including hemophore and ATP hydrolysis-driven transporter. In this review, recent discoveries in the molecular mechanism of the heme acquisition, membrane transport, degradation and sensing of the heme, with particular emphasis on the recognition of the heme and the dynamics of protein conformation from structural viewpoint.

収録刊行物

• 日本結晶学会誌

  日本結晶学会誌 59 (4), 166-173, 2017

  日本結晶学会

キーワード

• Earth-Surface Processes

詳細情報

• CRID: 1390282679064913024
• NII論文ID: 130006032057
• NII書誌ID: AN00188364
• DOI: 10.5940/jcrsj.59.166
• ISSN: 18845576
• ISSN: 03694585
• NDL書誌ID: 028522575
• Web Site: http://id.ndl.go.jp/bib/028522575
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028522575
• Web Site: https://www.jstage.jst.go.jp/article/jcrsj/59/4/59_166/_pdf
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可