Structural Biology of the Bacterial Heme Acquisition and Transport Systems

• SUGIMOTO Hiroshi

  RIKEN SPring-8 Center

Bibliographic Information

Other Title

• バクテリアにおけるヘムの獲得と輸送の構造生物学
• バクテリア ニ オケル ヘム ノ カクトク ト ユソウ ノ コウゾウ セイブツガク

Abstract

Iron is an essential element for almost all living organism as it serves as a catalytic center for redox and metabolic reactions in many enzymes. Bacterial pathogens have evolved the efficient systems for the heme acquisition to survive in the host tissues and body fluids, because the heme is a rich source of iron. Pathogens grab the heme from the host hemoproteins and import it into cytoplasm by using many proteins including hemophore and ATP hydrolysis-driven transporter. In this review, recent discoveries in the molecular mechanism of the heme acquisition, membrane transport, degradation and sensing of the heme, with particular emphasis on the recognition of the heme and the dynamics of protein conformation from structural viewpoint.

Journal

• Nihon Kessho Gakkaishi

  Nihon Kessho Gakkaishi 59 (4), 166-173, 2017

  The Crystallographic Society of Japan

Keywords

• Earth-Surface Processes

Details

• CRID: 1390282679064913024
• NII Article ID: 130006032057
• NII Book ID: AN00188364
• DOI: 10.5940/jcrsj.59.166
• ISSN: 18845576
• ISSN: 03694585
• NDL BIB ID: 028522575
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028522575
• Web Site: https://www.jstage.jst.go.jp/article/jcrsj/59/4/59_166/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed