微細構造をもつ膵島様組織の作製  [in Japanese] Development of islet-like tissues with microstructures  [in Japanese]

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Author(s)

    • 小島 伸彦 Kojima Nobuhiko
    • 横浜市立大学大学院生命ナノシステム科学研究科生命環境システム科学専攻再生生物学 Yokohama City University, Graduate School of Nanobioscience, Department of Life and Environmental System Science

Abstract

The pancreatic islet is a functional unit of the pancreatic endocrine system, and it has a potential to cure type 1 diabetes by transplantation. However, donor shortage is a serious problem. To solve this, it is suggested to use the islet-like tissues from pancreatic beta cell lines or iPS cell derived insulin-producing cells. In this paper, we introduce a three-dimensional culture method for constructing islet-like tissues with microstructures those can enhance the insulin secretion activity. The islet-like tissues showed higher insulin secretion activity by mixing α cells and/or hydrogel beads. Moreover, the islet-like tissues containing pancreatic alpha cells exhibited higher therapeutic performance when they were transplanted under the kidney capsules of the streptozotocin-induced diabetic mice. Achievement to develop more functional islet-like tissues results in a reduction of medical cost as well as cell number in transplantation. The concept of redesigning the microstructure of islet-like tissues may be effective for future transplantation treatment.

Journal

  • Organ Biology

    Organ Biology 24(2), 213-216, 2017

    The Japan Society for Organ Preservation and Biology

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