What is the necessary technique for the development of organ perfusion?

DOI
  • Fukai Moto
    Department of Transplant Surgery, Graduate School of Medicine, Hokkaido University
  • Shimada Shingo
    Department of Gastroenterological Surgery , Graduate School of Medicine, Hokkaido University
  • Umemoto Kouhei
    Department of Gastroenterological Surgery , Graduate School of Medicine, Hokkaido University
  • Nakayabu Takuya
    Department of Gastroenterological Surgery , Graduate School of Medicine, Hokkaido University
  • Kobayashi Nozomi
    Department of Gastroenterological Surgery , Graduate School of Medicine, Hokkaido University
  • Mino Kazuhiro
    Department of Gastroenterological Surgery , Graduate School of Medicine, Hokkaido University
  • Shimamura Tsuyoshi
    Division of Organ Transplantation, Hokkaido University Hospital
  • Taketomi Akinobu
    Department of Gastroenterological Surgery , Graduate School of Medicine, Hokkaido University

Bibliographic Information

Other Title
  • 臓器灌流法の先にあるべき技術とは？

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Abstract

Extensive efforts to repair the extended criteria donor (ECD) grafts by machine perfusion has been reported. Although the optimal conditions, such as the perfusate, temperature, time, and the device, has not yet been established, organ perfusion is generally accepted as a promising concept. Here, we review current progress of antioxidant and anti-inflammatory treatment by induction of protective transcription factors (TFs), Nrf2 in relation to the other TFs (AP-1 and NF-kB). These TFs are mainly regulated by the redox status of intracellular thiols. Possible interactions of the TFs and the methods to regulate their activity have been described.

Journal

  • Organ Biology

    Organ Biology 24 (2), 169-174, 2017

    The Japan Society for Organ Preservation and Biology

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