Dietary phosphate exacerbates intestinal inflammation in experimental colitis
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- Sugihara Kohei
- Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Masuda Masashi
- Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Nakao Mari
- Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Abuduli Maerjianghan
- Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Imi Yukiko
- Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Oda Naoko
- Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Okahisa Toshiya
- Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Yamamoto Hironori
- Department of Health and Nutrition, Faculty of Human Life, Jin-ai University
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- Takeda Eiji
- Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Taketani Yutaka
- Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School
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Abstract
<p>The recent widespread consumption of Western diets and food additives worldwide is associated with excessive inorganic phosphate intake. However, researchers have known little about the impact of dietary phosphate intake on the development of inflammatory bowel disease to date. In this study, we investigated the effects of dietary phosphate on intestinal inflammation in experimental colitis. Sprague-Dawley rats were fed different phosphate diets (0.5%, 1.0% and 1.5% phosphate) with or without dextran sulfate sodium. For in vitro study, the effects of phosphate on proinflammatory cytokine induction and reactive oxygen species production in RAW264.7 macrophage were examined. Dietary phosphate exacerbated intestinal inflammation in experimental colitis in a dose-dependent manner, as assessed by the clinical disease activity score, colon length, and histology. Furthermore, the high phosphate diet increased myeloperoxidase activity and proinflammatory cytokine mRNA expression through the activation of nuclear factor κB in the inflamed colon. In addition, high phosphate loading in RAW264.7 cells directly enhanced reactive oxygen species production and proinflammatory cytokine gene expression. Our results demonstrated that the high phosphate diet exacerbated intestinal inflammation in experimental colitis. These findings have important therapeutic implications for inflammatory bowel disease patients.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 61 (2), 91-99, 2017
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Details 詳細情報について
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- CRID
- 1390282679650052864
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- NII Article ID
- 130006038748
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed