Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome
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- Niegawa Tomomi
- Department of Pediatrics, Osaka Medical College
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- Takitani Kimitaka
- Department of Pediatrics, Osaka Medical College
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- Takaya Ryuzo
- Department of Pediatrics, Saiseikai Ibaraki Hospital
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- Ishiro Manabu
- Department of Pediatrics, Osaka Medical College
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- Kuroyanagi Yuichi
- Department of Pediatrics, Saiseikai Suita Hospital
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- Okasora Keisuke
- Department of Pediatrics, Hirakata City Hospital
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- Minami Yukako
- Department of Pediatrics, Osaka Medical College
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- Matsuda Takuya
- Department of Pediatrics, Osaka Medical College
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- Tamai Hiroshi
- Department of Pediatrics, Osaka Medical College
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Abstract
<p>Down syndrome, caused by trisomy 21, is characterized by congenital abnormalities as well as mental retardation. From the neonatal stage through adolescence, patients with Down syndrome often have several complications. Thus, it is important to attain knowledge of the prevalence of these comorbidities in children with Down syndrome. We, therefore, evaluated the biochemical data, thyroid function, and anthropometric parameters, and analyzed the association among them in Japanese children and early adolescents with Down syndrome. There was no difference in the prevalence of obesity and overweight between boys and girls. The level of uric acid was higher in boys than in girls. Moreover, the prevalence of hyperuricemia was also higher in boys than in girls (approximately 32% and 10%, respectively). The prevalence of subclinical hypothyroidism in children with Down syndrome was approximately 20%, with no significant sex differences. The levels of uric acid and dehydroepiandrosterone-sulfate were positively associated with age, while the levels of thyroid-stimulating hormone and free thyroxine had a negative association with age. Overall, children with Down syndrome, exhibit a higher incidence of hyperuricemia. Therefore, uric acid levels, as well as thyroid function, from childhood to early adulthood should be monitored in this patient cohort.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 61 (2), 146-152, 2017
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Details 詳細情報について
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- CRID
- 1390001204673361792
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- NII Article ID
- 130006038883
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed