1-Methoxypyrrole-2-carboxamide—A new pyrrole compound isolated from <i>Streptomyces griseocarneus</i> SWW368
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- Wattanasuepsin Watsapon
- Department of Biotechnology, Faculty of Science, Mahidol University Universityidol University-Osaka University Collaborative Research Center for Bioscience and Biotechnology (MU-OU:CRC), Faculty of Science, Mahidol University
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- Intra Bungonsiri
- Department of Biotechnology, Faculty of Science, Mahidol University Universityidol University-Osaka University Collaborative Research Center for Bioscience and Biotechnology (MU-OU:CRC), Faculty of Science, Mahidol University
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- Euanorasetr Jirayut
- Department of Microbiology, Faculty of Science, King Mongkut’s University of Technology Thonburi
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- Watanabe Yoshihiro
- Graduate School of Infection Control Sciences, Kitasato University
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- Mingma Ratchanee
- Kitasato Institute for Life Sciences, Kitasato University
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- Fukasawa Wataru
- Graduate School of Infection Control Sciences, Kitasato University
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- Mori Mihoko
- Graduate School of Infection Control Sciences, Kitasato University Kitasato Institute for Life Sciences, Kitasato University
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- Matsumoto Atsuko
- Graduate School of Infection Control Sciences, Kitasato University Kitasato Institute for Life Sciences, Kitasato University
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- Shiomi Kazuro
- Graduate School of Infection Control Sciences, Kitasato University Kitasato Institute for Life Sciences, Kitasato University
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- Panbangred Watanalai
- Department of Biotechnology, Faculty of Science, Mahidol University Universityidol University-Osaka University Collaborative Research Center for Bioscience and Biotechnology (MU-OU:CRC), Faculty of Science, Mahidol University
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Abstract
<p>A new pyrrole compound, 1-methoxypyrrole-2-carboxamide, was obtained from a culture broth of Streptomyces griseocarneus SWW368, which was isolated from the rhizospheric soil under a Para rubber tree (Hevea brasiliensis). The chemical structure was elucidated by 1D NMR, 2D NMR, and MS, as a pyrrole ring with a N-methoxy group and a primary amide group. It exhibited antibacterial properties against Kocuria rhizophila, Staphylococcus aureus and Xanthomonas campestris pv. oryzae; however, cytotoxicity of the compound at 714 μM against several mammalian tumor cell lines, i.e. A549, PANC1, HT29, HT1299 and HeLa S3, were not detected.</p>
Journal
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- The Journal of General and Applied Microbiology
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The Journal of General and Applied Microbiology 63 (4), 207-211, 2017
Applied Microbiology, Molecular and Cellular Biosciences Research Foundation
